Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell adhesion molecules and cancer.

J Fawcett1, A L Harris

  • 1University of Oxford, John Radcliffe Hospital, UK.

Current Opinion in Oncology
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Give CNAs a career ladder to climb.

Provider (Washington, D.C.)·2001
Same author

Human bladder cancer invasion model using rat bladder in vitro and its use to test mechanisms and therapeutic inhibitors of invasion.

British journal of cancer·2001
Same author

Exploring hemichannel permeability in vitro.

Methods in molecular biology (Clifton, N.J.)·2001
Same author

Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling.

Oncogene·2001
Same author

A phase II study of razoxane, an antiangiogenic topoisomerase II inhibitor, in renal cell cancer with assessment of potential surrogate markers of angiogenesis.

Clinical cancer research : an official journal of the American Association for Cancer Research·2001
Same author

Hypoxia-inducible expression of tumor-associated carbonic anhydrases.

Cancer research·2001

Cell adhesion molecules (proteins and carbohydrates on cell surfaces) are vital for cell functions. Altered expression of these molecules is common in cancer, impacting cell motility and development.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cell adhesion molecules (CAMs) are diverse glycoproteins on cell surfaces.
  • CAMs regulate critical cellular processes like development, differentiation, and motility.
  • Aberrant CAM expression is implicated in various diseases, particularly cancer.

Purpose of the Study:

  • To investigate the role of cell adhesion molecules in cancer.
  • To understand how disturbances in CAM expression contribute to malignancy.
  • To highlight the significance of CAMs in cancer biology.

Main Methods:

  • Analysis of cell surface protein and carbohydrate expression.
  • Molecular and biochemical techniques to study CAMs.
  • Comparative studies between normal and malignant cells.

Related Experiment Videos

Main Results:

  • Cell adhesion molecules are complex and varied.
  • CAMs play a crucial role in fundamental cell biology.
  • Expression patterns of CAMs are frequently altered in cancerous tissues.

Conclusions:

  • Disturbances in cell adhesion molecule expression are a hallmark of malignancy.
  • Understanding CAMs offers potential therapeutic targets for cancer.
  • CAMs are critical indicators and contributors to cancer progression.