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Updated: Aug 17, 2026
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Quantitative changes in thyroid lymphoid cells as a marker of malignancy
Vladimir A Kirillov1, Elena E Stebenyaeva, Andrey A Paplevka
1Laboratory for Electron Paramagnetic Resonance-Dosimetry and Cytology, Belarusian State Medical University, 23 Philimonova Street, Room 416, 220114 Minsk, Belarus. kirillov@msmi.minsk.by
Objective:
To investigate the possibility of using morphometric changes in lymphoid cells in thyroid tissue as a marker of malignant tumors.
Study Design:
Morphometry of biopsy material was performed with a semiautomated, computerized image analyzer.
Results:
Nine features were selected. These features formed the criteria for differentiation between malignant and benign disease. Equations for the calculation of a weighting coefficient for each feature and a diagnostic index were derived. The values for the diagnostic index for the groups with malignant and benign pathology differed significantly.
Conclusion:
One can determine the presence of a malignant tumor in the thyroid gland from the diagnostic index value.
