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Chemotherapy for advanced malignant melanoma.

A C Buzaid¹, J Murren

¹Department of Medicine, Yale University School of Medicine, New Haven, CT 06510.

International Journal of Clinical & Laboratory Research

|January 1, 1992

Summary

Chemotherapy for metastatic melanoma shows limited success. A combination regimen including tamoxifen demonstrates a 50% response rate, suggesting hormonal therapy

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Area of Science:

Oncology
Medical Research

Background:

Systemic chemotherapy for metastatic melanoma has yielded disappointing results.
No single agent has shown significant promise in treating this advanced cancer.

Purpose of the Study:

To evaluate the efficacy of a combination chemotherapy regimen including tamoxifen for metastatic melanoma.
To explore the role of hormonal therapy in conjunction with chemotherapy.

Main Methods:

Review of sequential small phase II trials.
Analysis of response rates and durability in patients treated with cisplatin, decarbazine, carmustine, and tamoxifen.
Consideration of biological response modifiers and their combination with cytotoxic agents.

Main Results:

The combination of cisplatin, decarbazine, carmustine, and tamoxifen achieved an overall response rate approaching 50%.
Durable responses exceeding 3 years were observed in some patients.
Tamoxifen appears to be a crucial component of this effective regimen.

Conclusions:

The combination of hormonal and chemotherapy, particularly with tamoxifen, shows significant promise for metastatic melanoma.
Further large-scale trials are needed to confirm these findings.
Future research should investigate novel agents and aggressive chemotherapy strategies for high-risk patients.

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