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Cerebrospinal fluid: postmortem biochemical study.

A Arroyo1, P Rosel, T Marron

  • 1Legal Medicine Institute of Catalunya, Barcelona, Spain. 8034aa@comb.es

Journal of Clinical Forensic Medicine
|May 26, 2005
PubMed
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Postmortem cerebrospinal fluid (CSF) analysis revealed significant differences in urea, protein, alkaline phosphatase, and cortisol levels based on age and cause of death. These findings highlight the impact of postmortem changes on biochemical markers.

Area of Science:

  • Biochemistry
  • Forensic Science
  • Neurology

Background:

  • Postmortem changes can significantly alter biochemical composition of body fluids.
  • Cerebrospinal fluid (CSF) is a valuable biofluid for postmortem analysis.
  • Understanding these alterations is crucial for accurate interpretation of forensic and clinical data.

Purpose of the Study:

  • To analyze urea, glucose, potassium, chloride, protein, creatinine, calcium, alkaline phosphatase, and cortisol in postmortem CSF.
  • To compare CSF biochemical profiles across different age groups.
  • To investigate differences based on the presence of mental/neurological illness and cause of death (natural vs. violent).

Main Methods:

  • CSF samples were collected from 55 corpses.
  • Samples were obtained via lateral ventricles after corpus callosus section.

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  • Samples were stored at -80°C until analysis.

    • Main Results:

    • Significant differences in urea levels were observed between age groups.
    • Protein levels differed significantly between natural and violent death groups.
    • Alkaline phosphatase and cortisol levels showed significant variations across age groups and between natural and violent death groups.

    Conclusions:

    • Postmortem CSF biochemical profiles are influenced by age and cause of death.
    • Further research is needed with clearly defined diagnostic groups (mental/degenerative disorders) and diverse age cohorts.
    • These findings underscore the importance of considering postmortem interval and demographic factors in CSF analysis.