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Updated: Aug 1, 2026

Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
Published on: October 29, 2014
Infected neonatal cephalohematomas caused by anaerobic bacteria
1Department of Pediatrics, Georgetown University School of Medicine, Washington, DC, USA. ib6@georgetown.edu
Objective:
To present the microbiological and clinical features of six children with infected cephalohematomas (IC) caused by anaerobic bacteria.
Design:
Presentation of a case series.
Results:
Polymicrobial infection was present in all instances, where the number of isolates varied from two to four. Two patients had anaerobes only and the other four had mixed flora of strict anaerobes and facultatives. There were 16 bacterial isolates (12 anaerobic, 4 aerobic). The anaerobic isolates were Peptostreptococcus spp. (5 isolates), Prevotella spp. (4), Bacteroides fragilis group (2), and Propionibacterium acnes (1). The aerobic isolates were E. coli (2), Staphylococcus aureus (1) and group B streptococci (1). Blood cultures were positive for three patients. The most common predisposing conditions were vacuum extraction and amnionitis (4 instances of each), instrumental delivery (3), electronic fetal monitoring (2), prolonged delivery (1), and premature rupture of membranes (1). All patients underwent drainage, and four also had surgical incision and drainage of the IC. Osteomyelitis developed in one instance and scalp abscess developed in two patients, both of whom had electronic fetal monitoring. All patients eventually recovered from infection after receiving parenteral and subsequent oral antibiotic therapy for a total of 14-38 days.
Conclusion:
This study highlights the polymicrobial nature and potential importance of anaerobic bacteria in IC in newborns.
Insights
Anaerobic bacteria are key players in infected cephalohematomas (IC) in newborns, often causing polymicrobial infections. Prompt antibiotic treatment is crucial for recovery.
Area of Science:
- Neonatal infections
- Microbiology
- Pediatric surgery
Background:
- Infected cephalohematomas (IC) are a rare but serious complication in newborns.
- The role of anaerobic bacteria in IC has not been extensively studied.
Observation:
- A case series of six infants with IC caused by anaerobic bacteria was analyzed.
- All cases presented polymicrobial infections, with 2 to 4 bacterial isolates.
- Common predisposing factors included vacuum extraction, amnionitis, and instrumental delivery.
Findings:
- Twelve anaerobic isolates were identified, including Peptostreptococcus spp., Prevotella spp., Bacteroides fragilis group, and Propionibacterium acnes.
- Four aerobic isolates were also found: E. coli, Staphylococcus aureus, and group B streptococci.
- Three patients had positive blood cultures; one developed osteomyelitis, and two had scalp abscesses.
Implications:
- This study underscores the significant involvement of anaerobic bacteria in neonatal infected cephalohematomas.
- Early diagnosis and appropriate antibiotic therapy, including anaerobic coverage, are essential for successful management.
- Further research into the specific role of different anaerobic species in IC is warranted.
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