Jove
Visualize
Contact Us

Related Experiment Videos

Teaching resources. Proteases and signaling.

Sherwin Wilk1

  • 1Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA. sherwin.wilk@mssm.edu

Science'S STKE : Signal Transduction Knowledge Environment
|May 26, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chloride channel ClC-5 binds to aspartyl aminopeptidase to regulate renal albumin endocytosis.

American journal of physiology. Renal physiology·2015
Same author

Oligomers of mutant glial fibrillary acidic protein (GFAP) Inhibit the proteasome system in alexander disease astrocytes, and the small heat shock protein alphaB-crystallin reverses the inhibition.

The Journal of biological chemistry·2010
Same author

Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2.

Neuro-degenerative diseases·2007
Same author

Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.

Biochemistry·2006
Same author

6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation.

The Journal of biological chemistry·2006
Same author

Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins.

The Biochemical journal·2005
Same journal

Identification of redox-active cell-surface proteins by mechanism-based kinetic trapping.

Science's STKE : signal transduction knowledge environment·2007
Same journal

Image correlation spectroscopy.

Science's STKE : signal transduction knowledge environment·2007
Same journal

Studies of SARM1 uncover similarities between immune and neuronal responses to danger.

Science's STKE : signal transduction knowledge environment·2007
Same journal

A discrete signaling function for an inositol pyrophosphate.

Science's STKE : signal transduction knowledge environment·2007
Same journal

Putting on the RITz.

Science's STKE : signal transduction knowledge environment·2007
Same journal

Type I interferons as anti-inflammatory mediators.

Science's STKE : signal transduction knowledge environment·2007
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

This resource covers proteases and cell signaling, focusing on protease-activated receptors and the ubiquitin-proteasome system. It explains how proteolysis regulates signal transduction pathways for graduate students.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cell signaling is a fundamental biological process.
  • Proteases play diverse roles within cellular mechanisms.
  • Understanding proteolysis in signaling is crucial for advanced biological studies.

Purpose of the Study:

  • To provide lecture materials on proteases and cell signaling.
  • To elucidate the role of protease-activated receptors (PARs) in cell communication.
  • To explain the involvement of the ubiquitin-proteasome system (UPS) in signaling.
  • To detail how proteolysis contributes to signal transduction pathways.

Main Methods:

  • Lecture notes and slides compilation.
  • Review of existing literature on proteases, PARs, UPS, and signal transduction.

Related Experiment Videos

  • Conceptual explanation of molecular mechanisms.

    • Main Results:

    • Detailed explanation of protease-activated receptors.
    • Description of the ubiquitin-proteasome system's role in signaling.
    • Illustrations of proteolysis as a mechanism in signal transduction.

    Conclusions:

    • Proteases are integral components of cell signaling systems.
    • PARs and the UPS are key examples of protease involvement in signaling.
    • Proteolysis is a versatile mechanism regulating cellular communication.