Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. Research Domains

Physical activity and survival after breast cancer diagnosis.

Michelle D Holmes1, Wendy Y Chen, Diane Feskanich

  • 1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115, USA. michelle.holmes@channing.harvard.edu

JAMA
|May 26, 2005

Related Experiment Videos

View abstract on PubMed

Summary
This summary is machine-generated.

Related Concept Videos

  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Physical Activity And Survival After Breast Cancer Diagnosis.

    • Engaging in regular physical activity after a breast cancer diagnosis significantly lowers mortality risk. Women meeting physical activity guidelines may improve survival rates, especially those with hormone-responsive tumors.

    Area of Science:

    • Oncology
    • Epidemiology
    • Public Health

    Background:

    • Physical activity is linked to reduced breast cancer incidence.
    • Its impact on recurrence and survival post-diagnosis remains unclear.

    Purpose of the Study:

    • To investigate the association between physical activity levels and breast cancer mortality.
    • To determine if post-diagnosis physical activity influences survival outcomes.

    Main Methods:

    • Prospective observational study of 2987 female nurses diagnosed with stage I-III breast cancer.
    • Follow-up until death or June 2002, assessing mortality risk by physical activity (MET-hours/week).

    Main Results:

    • Higher physical activity (≥9 MET-hours/week) correlated with reduced breast cancer mortality risk (RR=0.50).
    • Significant benefits observed in women with hormone-responsive tumors (RR=0.50).
    • Approximately 6% absolute mortality risk reduction at 10 years for active women (≥9 MET-hours/week).

    Conclusions:

    • Post-diagnosis physical activity may decrease breast cancer death risk.
    • Optimal benefit observed with 3-5 hours/week of walking; greater intensity showed diminishing returns.
    • Adhering to physical activity recommendations can enhance survival for breast cancer patients.

    Related Experiment Videos