Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Improving agglutination tests by working in microfluidic channels.

G Degré1, E Brunet, A Dodge

  • 1Microfluidics, MEMS, Nanostructure, Ecole Superieure de Physique et Chimie Industrielle, 10 rue Vauquelin, 75231, Paris, France.

Lab on a Chip
|May 26, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Equations of motion of a track cyclist: Active particle dynamics under strong geometric constraints.

Physical review. E·2025
Same author

Types, behaviour and therapeutic requirements of inflammatory pouch disorders: Results from the RESERVO study of GETECCU.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2024
Same author

Acute effect of biomechanical foot orthotics on gross efficiency in cyclists affected by an anatomic asymmetry in time trial position.

Computer methods in biomechanics and biomedical engineering·2017
Same author

Microfluidic step-emulsification in axisymmetric geometry.

Lab on a chip·2017
Same author

Correction: Step-emulsification in a microfluidic device.

Lab on a chip·2015
Same author

Step-emulsification in a microfluidic device.

Lab on a chip·2014
Same journal

Microfluidic rare cell analysis beyond counting: workflow design from enrichment to multi-omics.

Lab on a chip·2026
Same journal

A sperm racetrack to separate sperm by swim speed.

Lab on a chip·2026
Same journal

Controlled encapsulation and droplet size prediction in two-step microfluidic double emulsions.

Lab on a chip·2026
Same journal

A particulate blood-mimicking fluid with physiological biconcave geometry for microscale hemorheology.

Lab on a chip·2026
Same journal

Multicellular sensor arrays fabricated by capillary stamping for pattern-based odor discrimination.

Lab on a chip·2026
Same journal

A real-time microfluidic surveillance system for multiplex detection of heavy metal contamination in wastewater.

Lab on a chip·2026
See all related articles

Microfluidic latex agglutination tests enhance disease diagnosis sensitivity and speed. This novel format improves upon traditional methods, offering faster, more accurate results for medical and veterinary applications.

Area of Science:

  • Biotechnology
  • Medical Diagnostics
  • Microfluidics

Background:

  • Latex agglutination tests are standard for disease diagnosis due to simplicity and low cost.
  • Traditional methods can be limited in sensitivity and speed.

Purpose of the Study:

  • To adapt latex agglutination tests into a microfluidic format.
  • To improve the analytical sensitivity and response time of agglutination assays.

Main Methods:

  • Utilized polydimethylsiloxane (PDMS) microchannels for the assay.
  • Employed streptavidin-coated superparamagnetic beads and a magnetic field for detection.
  • Target molecule: biotinylated protein A.

Main Results:

  • Achieved an analytical sensitivity of 10 fmol L⁻¹ (hundreds of fg mL⁻¹).

Related Experiment Videos

  • Demonstrated a rapid response time of a few minutes.
  • The microfluidic test was quantitative.

    • Conclusions:

    • Microfluidic adaptation significantly enhances latex agglutination test performance.
    • This approach offers orders of magnitude improvement in sensitivity and speed.
    • The technology integrates advantages like miniaturization and high throughput for diagnostics.