Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Early development of the human mesonephros.

K S Ludwig¹, L Landmann

¹Department of Anatomy, University of Basel, Pestalozzistr. 20, 4056 Basel, Switzerland.

Anatomy and Embryology

|May 26, 2005

Summary

The mesonephric cord forms early kidney structures, including the mesoureter and nephron anlage, through distinct cellular transformations. These processes establish the foundation for developing functional kidney tubules and collecting systems.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2.

Cellular and molecular life sciences : CMLS·2008

Same author

A novel antiapoptotic mechanism based on interference of Fas signaling by CD44 variant isoforms.

Cell death and differentiation·2005

Same author

Synapses form in skeletal muscles lacking neuregulin receptors.

Science (New York, N.Y.)·2005

Same author

Deconvolution improves colocalization analysis of multiple fluorochromes in 3D confocal data sets more than filtering techniques.

Journal of microscopy·2002

Same author

Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3.

Pflugers Archiv : European journal of physiology·2001

Same author

Cellular COPII proteins are involved in production of the vesicles that form the poliovirus replication complex.

Journal of virology·2001

Area of Science:

Embryology
Developmental Biology
Urology

Background:

The formation of the mesonephros (Wolffian body) is a critical early developmental stage in vertebrate kidney development.
Understanding the cellular origins and transformations within the mesonephric cord is essential for comprehending nephrogenesis.

Purpose of the Study:

To elucidate the detailed cellular processes involved in the differentiation of the mesonephric cord and its associated structures.
To describe the morphological changes leading to the formation of the nephron anlage, mesoureter, and collecting tubules.

Main Methods:

Histological analysis of embryonic tissues.
Detailed morphological observation of cellular differentiation and tissue morphogenesis.

Main Results:

The mesonephric cord fragments into provesicular cell masses interacting with the mesonephric duct.
These structures undergo complex transformations, forming a 'distillation flask' and 'outlet pipe' that develop into the corpusculum and tubules, respectively.
The mesonephric duct epithelium differentiates into a multilayered cone, forming the mesoureter, with distinct morphologies in the epigenitale and paragenitale regions.

Conclusions:

The study details a precise sequence of cellular events driving mesonephric kidney development.
Differential epithelial differentiation within the mesoureter is observed based on the specific developmental region (epi- vs. paragenitale).

Related Experiment Videos