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Ethyl alpha-D-glucoside increases urine volume and causes renal morphologic changes in rats
Tomoyuki Mishima1, Yumiko Katayama, Yoshie Takagi
1The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. h6103007@guedu.cc.gifu-u.ac.jp
Journal of Nutritional Science and Vitaminology
|May 27, 2005
Summary
Ethyl alpha-D-glucoside (alpha-EG), found in sake, increases urine volume and kidney weight in rats after ingestion. This occurs without causing damage to renal cells or affecting kidney function, indicating safe excretion.
Area of Science:
- Biochemistry
- Nephrology
- Food Science
Background:
- Ethyl alpha-D-glucoside (alpha-EG) is a unique component present in sake.
- Its physiological effects, particularly on renal function, are not well understood.
Purpose of the Study:
- To investigate the morphological changes in the kidney and the effects on urine excretion following alpha-EG ingestion in rats.
Main Methods:
- Rats were fed diets containing 20% or 100% alpha-EG.
- Urine and plasma samples were analyzed.
- Kidney morphology was examined histopathologically.
Main Results:
- Alpha-EG was detected in the urine of ingested rats.
- A significant increase in urine volume and kidney weight was observed.
- Renal tubules showed dilation, but no histopathological damage to renal cells was detected.
- Plasma uric acid and urea levels remained unaffected.
Conclusions:
- Ingested alpha-EG is excreted via urine, leading to increased urine volume.
- Kidney weight increase is associated with renal tubule dilation, without detrimental effects on renal cells or function.