[Investigation of lipoprotein metabolism in persons with abstinence]

Lipoprotein (LP) metabolism was investigated in the blood serum of persons with abstinence after ethanol intake in a single dose of (0.7-1.0) g/kg. Content of LP was determined with the method of gradient gel-electrophoresis and use of software for quantitative analysis. A LP-lipase and cholesteroletherificazing activity of blood serum were also examined. It was found out that the patients with abstinence were characterized by the slowing down of LP metabolism as compared with donors, who represented general population. A single action of ethanol causes a short-time inhibition of LP metabolism. After 3 days processes of apoA-containing LP transformation were renewed. In contrast to this, one could observe an increase of the level of apoB-containing fractions accompanied by incompatibility between quantitative LP changes and activities of enzymes, which catalyzed their transformation. This evidences for the impairment of coordination of processes of cholesterol and triacylglyceroles transport by ethanol.