Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central conduction time in childhood autism.

R J McClelland1, D G Eyre, D Watson

  • 1Department of Mental Health, Queen's University, Belfast.

The British Journal of Psychiatry : the Journal of Mental Science
|May 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integration of genomic aberrations to predict clinical outcomes for patients with gastroesophageal adenocarcinoma receiving neoadjuvant chemotherapy.

ESMO gastrointestinal oncology·2026
Same author

Little red dots as young supermassive black holes in dense ionized cocoons.

Nature·2026
Same author

A standard operating procedure for reducing risk from medications prohibited during clinical trials in cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2025
Same author

Correction: The effect of a single, large bolus of vitamin D in healthy adults over the winter and following year: a randomized, double-blind, placebo-controlled trial.

European journal of clinical nutrition·2023
Same author

Narrowing the gap between research and policy: using rapid evaluation during the COVID-19 crisis.

Perspectives in public health·2023
Same author

An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression.

Science translational medicine·2022

Brain-stem auditory evoked potentials revealed delayed central conduction times in autistic children over 14, suggesting a maturational myelination defect in autism affecting brain-stem integrity.

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Clinical Audiology

Background:

  • Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition.
  • Previous research suggests potential neurological differences in individuals with autism.
  • Brain-stem auditory evoked potentials (BAEPs) are a non-invasive tool to assess auditory pathway integrity.

Purpose of the Study:

  • To investigate the brain-stem auditory pathway integrity in children with autism.
  • To determine if there are age-related differences in brain-stem conduction in autistic children.
  • To compare brain-stem function in autistic children with non-autistic mentally handicapped children.

Main Methods:

  • Brain-stem auditory evoked potentials (BAEPs) were recorded in 20 children meeting Rutter criteria for autism.

Related Experiment Videos

  • Stimulus intensities varied to assess central conduction times (CCTs) within the Wave I-Wave V interval.
  • Results were compared to age- and sex-matched controls and non-autistic mentally handicapped children.

    • Main Results:

    • Children under 14 years with autism showed normal CCTs.
    • Autistic children aged 14 and over exhibited prolonged CCTs, particularly boys.
    • Non-autistic mentally handicapped children had normal CCTs, distinguishing them from the autistic group.

    Conclusions:

    • Findings suggest a maturational defect in brain-stem myelination in autism, potentially linked to age.
    • This defect may indicate a broader anatomical distribution of neurological abnormalities in autism.
    • Further research is warranted to explore the extent and implications of these maturational deficits.