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Updated: Aug 17, 2026

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Update on using coronary calcium screening by computed tomography to measure risk for coronary heart disease
Brad H Thompson1, William Stanford
1Department of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa Health Care, Iowa City, USA. brad-thompson@uiowa.edu
Insights
Coronary arterial calcium (CAC) screening using computed tomography accurately assesses coronary artery disease (CAD) severity. CAC quantification helps predict coronary heart disease (CHD) risk and guides prevention strategies.
Area of Science:
- Cardiology
- Radiology
- Preventive Medicine
Background:
- Coronary artery disease (CAD) is a leading cause of death in the US.
- Early detection and prevention are crucial for reducing heart disease mortality.
- Coronary arterial calcium (CAC) serves as a marker for arteriosclerosis and overall disease severity.
Purpose of the Study:
- To review evidence validating CAC screening as a tool for coronary heart disease (CHD) risk prediction.
- To assess the utility of CAC quantification in identifying patients at higher risk for cardiac events.
Main Methods:
- Computed tomography (CT) is used for non-invasive quantification of coronary calcification burden.
- CAC measurements are correlated with histological plaque analyses to validate accuracy.
Main Results:
- CAC measurements accurately reflect CAD severity.
- Higher calcium burdens correlate with advanced CAD, coronary stenoses, and increased risk of acute cardiac events.
- CT-based CAC quantification shows good correlation with histological findings.
Conclusions:
- CAC screening is a valuable tool for assessing individual risk for CHD.
- CAC quantification aids in identifying patients with significant coronary calcification and higher cardiac event risk.
- This evidence supports the use of CAC screening in clinical practice for risk stratification.
Abstract:
Coronary artery disease (CAD) is the number one killer of adults in the United States, claiming one-half million deaths annually. Early detection and prevention strategies clearly remain a top priority for health care providers in order to reduce the high mortality rate of heart disease. As an unequivocal reflection of arteriosclerosis, coronary arterial calcium (CAC) may provide a means to qualitatively assess the overall disease severity and likewise serve as a means to assess risk for CHD. It is known that patients with heavy calcium burdens have more advanced CAD, a concomitantly a higher likelihood of coronary stenoses, and a concomitant higher risk for acute cardiac events. Computed tomography has been shown to be an accurate, non-invasive method to quantify coronary calcification burden in patients. Evidence shows that calcium measurements by CT correlate well with histological plaque analyses, and that CAC measurements accurately reflect disease severity and can be useful to assess individual risk for CHD. The purpose of this article is to summarize the currently available evidence that has attempted to validate CAC screening as a screening exam and risk predictor for coronary heart disease.
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