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[Actinomycetomas in Senegal: study of 90 cases]

M T Dieng1, S O Niang, B Diop

  • 1Service de dermatologie, CHU Le Dantec, BP 3001, Dakar, Sénégal. mftd@sentoo.sn

Bulletin De La Societe De Pathologie Exotique (1990)
|May 27, 2005
PubMed

Insights

Actinomycetoma, a fungal infection, commonly affects adult males in Senegal, presenting as tumors or pain. Oral sulfametoxazole achieved an 83% cure rate in a study of 90 patients.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Dermatology

Context:

  • Mycetoma is a chronic granulomatous disease caused by fungi or actinomycetes.
  • Actinomycetoma, a subtype, is treatable with medication, unlike eumycetoma which often requires surgery.
  • This study focuses on actinomycetoma cases in male adults from central Senegal.

Purpose:

  • To describe the clinical features, etiological agents, and treatment outcomes of actinomycetoma in a Senegalese population.
  • To evaluate the efficacy of sulfametoxazole in treating actinomycetoma.

Summary:

  • Ninety male adult patients with actinomycetoma were analyzed.
  • The primary causative agents identified were Actinomadura pelletieri (60 cases), Actinomadura madurae (25 cases), and Streptomyces somaliensis (5 cases).
  • Clinical presentations included inflammatory (75 cases), tumoral (13 cases), and cystic (2 cases) forms, with lesions frequently on the foot (50%) and associated bone damage (55%).

Impact:

  • An 83% cure rate was observed after one year of oral sulfametoxazole treatment.
  • The findings highlight sulfametoxazole as an effective treatment for actinomycetoma.
  • Two cases resulted in mortality due to visceral involvement, underscoring the potential severity of the disease.

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