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Updated: Aug 17, 2026
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
Sublingual specific immunotherapy reduces PBMC proliferations
D Fenoglio1, F Puppo, I Cirillo
1DIMI-CEBR, Università di Genova, Genoa, Italy.
Background:
Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy.
Objective:
The aim of this study was to evaluate T cell proliferation in subjects successfully treated with SLIT for HDM.
Methods:
PBMCs were isolated from patients after at least 3 years of successful HDM SLIT and from matched untreated allergic and healthy control subjects. After 3 and 6 days of in vitro stimulation with PHA, Candida albicans, Dermatophagoides farinae, grasses, Parietaria judaica, and cat, proliferation.
Results:
Subjects treated with SLIT showed significant reduction of proliferation induced by Candida albicans, Parietaria, and grasses in comparison with untreated atopics (p=0.0002, 0.0033, and 0.009 respectively).
Conclusion:
This pilot study confirms reduced T cell proliferation in allergic subjects treated with SLIT.
