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Bacterial isolation and antimicrobial susceptibilities in patients with infective endocarditis

Somporn Srifuengfung1, Thitiya Yungyuen, Podjanee Komolpis

  • 1Department of Microbiology, Faculty of Medicine at Siriraj Hospital, Mahidol University, Bangkok, Thailand. sissf@mahidol.ac.th

The Southeast Asian Journal of Tropical Medicine and Public Health
|May 27, 2005
PubMed

Insights

Infective endocarditis treatment requires prompt action. Nonfermentative gram-negative rods were the most common bacterial cause in a 20-year study, showing high sensitivity to cefoperazone/sulbactam and piperacillin/tazobactam.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Clinical Medicine

Background:

  • Infective endocarditis (IE) is a severe infection requiring timely intervention.
  • A comprehensive understanding of causative pathogens and their antibiotic sensitivities is crucial for effective treatment.
  • This study analyzes a large cohort over two decades to provide updated epidemiological data.

Purpose of the Study:

  • To investigate the epidemiological characteristics of infective endocarditis.
  • To identify the most common bacterial pathogens causing IE.
  • To evaluate the antibiotic susceptibility patterns of these pathogens.

Main Methods:

  • Retrospective analysis of 6217 patients diagnosed with infective endocarditis between 1982 and 2001.
  • Data collection primarily from hemoculture results.
  • Identification and susceptibility testing of bacterial isolates.

Main Results:

  • Bacterial pathogens were identified in 13.41% of patients.
  • Nonfermentative gram-negative rods (N.F.) were the most frequent pathogens (20.94%).
  • Other common pathogens included coagulase-negative staphylococci, viridans streptococci, Staphylococcus aureus, and Escherichia coli.
  • N.F. demonstrated high sensitivity to cefoperazone/sulbactam (86%) and piperacillin/tazobactam (86%).

Conclusions:

  • Nonfermentative gram-negative rods represent a significant etiological agent in infective endocarditis.
  • Antibiotics such as cefoperazone/sulbactam and piperacillin/tazobactam are effective against this group of pathogens.
  • Continued surveillance of IE pathogens and resistance patterns is essential for guiding clinical practice.

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