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Updated: Aug 17, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

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Published on: September 16, 2017

Tumor necrosis factor alpha inhibitors for the treatment of dermatologic diseases

Jennifer T Trent1, Francisco A Kerdel

  • 1Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Miami, FL, USA.

Dermatology Nursing
|May 27, 2005
PubMed

Tumor necrosis factor alpha (TNFalpha) is involved in cell differentiation, mitogenesis, cytotoxic responses, inflammation, immunomodulation, and wound healing. Because of its numerous roles, it was thought that inhibition of TNF may aid in the treatment of certain dermatologic diseases such as psoriasis, hidradentitis suppurativa, pyoderma gangrenosum, Behcet 's syndrome, and graft versus host disease. The efficacy of these agents has proven impressive and short-term side effects have been few and relatively benign.

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