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Updated: Aug 17, 2026

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
Published on: September 5, 2011
Elevated maternal glucose concentrations and placental infection in twin pregnancies
Barbara Luke1, Morton B Brown, Ruta B Misiunas
1Departments of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, Florida, USA. b.luke@miami.edu
Objective:
To evaluate the association between maternal screening glucose concentration and placental infection in nondiabetic twin pregnancies.
Study Design:
One thousand sixty-one nondiabetic twin pregnancies at > or =28 weeks' gestation were divided into 3 groups based on the screening 50-g fasting glucose concentration at 24-28 weeks: lowest quartile (< 96 mg/dL), middle 2 quartiles (96-128 mg/dL) and upper quartile (> 128 mg/dL). Outcomes were modeled using general linear and multinomial logistic regression, controlling for confounding factors.
Results:
The middle and highest glucose groups were associated with increased risks for clinical chorioamnionitis (adjusted OR [AOR] 3.18, 95% CI 1.34, 7.54; AOR 6.80, CI 1.89, 24.53, respectively). Birth at <32 weeks and histologic diagnosis of placental infection (chorioamnionitis, funisitis, necrosis, vasculitis or villitis) were significantly associated only with the highest glucose group (AOR 1.79, CI 1.02, 3.13; AOR 6.95, CI 1.10, 8.68, respectively).
Conclusion:
Elevated screening glucose in nondiabetic twin pregnancies may be a marker of placental inflammation and infection.
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