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Synthetic iminosugar derivatives as new potential immunosuppressive agents
Xin-Shan Ye1, Fang Sun, Min Liu
1The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Xue Yuan Road #38, Beijing 100083, China. xinshan@bjmu.edu.cn
Abstract:
Several iminosugar derivatives were synthesized, and their effects on the secretion of IL-4 and IFN-gamma from the mouse splenocytes were examined. The effects on membrane expression of other T cell-associated molecules (CD3, CD4, CD8) and B cell-associated molecules (CD19) were also investigated. The experimental data demonstrated that synthetic iminosugars hold potential as immunosuppressive agents.
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