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Nanomanipulation of Single RNA Molecules by Optical Tweezers
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Linkage between proton binding and folding in RNA: implications for RNA catalysis

P C Bevilacqua1, T S Brown, D Chadalavada

  • 1Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA. pcb@chem.psu.edu

Biochemical Society Transactions
|May 27, 2005
PubMed
Summary

Small ribozymes, like the hepatitis delta virus ribozyme, use nucleobases for catalysis. Folding and protonation linkage enhances RNA function by shifting nucleobase pKa values.

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