Related Experiment Video

Updated: Jul 29, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
07:13

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Effects of acute hypercalcaemia on blood pressure in subjects with and without parathyroid hormone secretion

E Kamycheva1, R Jorde, E Haug

  • 1Department of Medicine, University Hospital of North Norway, Tromsø, Norway. elena.kamycheva@unn.no

Acta Physiologica Scandinavica
|May 27, 2005
PubMed

Insights

Acute hypercalcemia increases blood pressure, but the mechanism is unclear. A decrease in parathyroid hormone (PTH) secretion may contribute to this rise, suggesting PTH

Area of Science:

  • Endocrinology
  • Cardiovascular Physiology

Background:

  • Acute hypercalcemia is known to elevate blood pressure.
  • The precise mechanism behind this hypertensive effect remains uncertain.
  • Parathyroid hormone (PTH) may influence blood pressure due to its vasodilatory properties, and its secretion decreases during hypercalcemia.

Purpose of the Study:

  • To investigate the role of parathyroid hormone (PTH) secretion in the blood pressure response to acute hypercalcemia.
  • To differentiate the effects of hypercalcemia from the effects of reduced PTH levels on blood pressure.

Main Methods:

  • A calcium clamp technique was used to induce controlled hypercalcemia in two steps.
  • The study included seven thyroparathyroidectomized subjects (with undetectable PTH) and ten control subjects.
  • Subjects underwent both a calcium infusion and a placebo infusion on separate occasions.

Main Results:

  • Systolic blood pressure significantly increased in control subjects during calcium infusion but not in thyroparathyroidectomized subjects.
  • Serum PTH levels decreased promptly in controls during hypercalcemia.
  • Hypercalcemia led to increased serum phosphate in both groups, but did not affect diastolic blood pressure, heart rate, or levels of catecholamines, renin, or aldosterone.

Conclusions:

  • The blood pressure increase during acute hypercalcemia is not mediated by catecholamine secretion or the renin-aldosterone system.
  • The observed fall in parathyroid hormone (PTH) secretion appears to play a contributory role in the hypertensive response to acute hypercalcemia.
Abstract

More Related Videos

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

Published on: August 17, 2022

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Related Concept Videos

Alterations in Blood Pressure01:30

Alterations in Blood Pressure

Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...