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Related Experiment Videos

Datura delirium.

J P Hanna1, J W Schmidley, W E Braselton

  • 1Department of Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio.

Clinical Neuropharmacology
|April 11, 1992
PubMed
Summary
This summary is machine-generated.

Tropine alkaloid poisoning from Datura innoxia can cause toxic delirium and coma. Specific assays are needed as routine screens may miss these anticholinergic compounds.

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Area of Science:

  • Toxicology
  • Pharmacology
  • Ethnobotany

Background:

  • Tropine alkaloids, found in plants like Datura innoxia and pharmaceuticals, can cause severe neurological symptoms.
  • Poisoning incidents are uncommon but can lead to significant morbidity, including delirium and coma.

Observation:

  • A case of toxic delirium and coma following ingestion of Datura innoxia root is presented.
  • Chemical analysis confirmed the presence of atropine and scopolamine in the ingested plant material.

Findings:

  • Routine clinical toxicology screens often lack assays for tropine alkaloids.
  • Specific tropine alkaloid testing can provide crucial diagnostic support.

Implications:

  • Enhanced diagnostic capabilities for tropine alkaloid poisoning are necessary.
  • Understanding the clinical, electroencephalographic, and therapeutic aspects of anticholinergic poisoning is vital for patient management.