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Updated: Aug 17, 2026

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
Squamous cell carcinoma arising in a tall cell papillary carcinoma of the thyroid
J Sutak1, J S Armstrong, J E Rusby
1Department of Histopathology, Great Western Hospital, Swindon and Marlborough NHS Trust, Marlborough Road, Swindon SN3 6BB, UK.
Abstract:
Transformation of differentiated thyroid cancer into poorly differentiated carcinoma is rare. This report describes a case in which preoperative fine needle aspiration suggested a squamous cell carcinoma whereas needle core biopsy favoured an undifferentiated carcinoma of probable thyroid origin. Histology of the subsequent total thyroidectomy specimen revealed a biphasic tumour comprising areas of tall cell papillary carcinoma merging with moderately to poorly differentiated squamous cell carcinoma. The immunohistochemical findings are discussed in detail.
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