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Pharmaceutical availability of gliclazide from selected matrix formulation tablets.

Tadeusz W Hermann¹, Roman Dobrucki, Stafan Piechocki

¹Department of Physical Pharmacy and Pharmacokinetics, University of Medical Sciences, Poznań, Poland. hermann@amp.edu.pl

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research

|May 27, 2005

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This study compared gliclazide release from existing and novel matrix tablets. Modified-release gliclazide tablets demonstrated zero-order release kinetics, differing from immediate-release formulations.

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems

Background:

Gliclazide is available in immediate-release (IR) and modified-release (MR) formulations.
Existing gliclazide tablets exhibit rapid drug release profiles.

Purpose of the Study:

To compare the gliclazide release kinetics of commercially available formulations.
To develop and evaluate a novel gliclazide matrix tablet formulation.

Main Methods:

Dissolution testing (BP 2001) was conducted on various gliclazide tablets.
Water solubility of gliclazide samples was determined using UV spectrometry.
Mean dissolution time (MDT) was calculated to classify release profiles.

Main Results:

Immediate-release tablets (diabezidum, diabrezide) released ~99% of gliclazide within 100 minutes.

Related Experiment Videos

Modified-release diaprel tablets showed 67% release at 8 hours.

Novel matrix tablets (C) exhibited a release profile similar to diaprel MR tablets.

MDT ranged from 4.6-76.4 min for IR and 279.6-701.2 min for SR tablets.

Conclusions:

Immediate-release gliclazide tablet dissolution follows first-order kinetics.
Modified-release gliclazide tablet dissolution follows zero-order kinetics.