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HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis

A C Lyra1, J R R Pinho, L K Silva

  • 1Departamento de Gastroenterologia, Universidade de São Paulo, São Paulo, SP, Brasil. aclyra@atarde.com.br

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|May 27, 2005
PubMed

Insights

Hepatitis E virus (HEV) co-infection was found in some acute hepatitis A cases, suggesting HEV may cause some sporadic non-A-C hepatitis. Torque teno virus (TTV) and GB virus C (GBV-C)/Hepatitis G virus (HGV) were common but not linked to acute hepatitis etiology.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Hepatitis viral infections pose a significant global health burden.
  • The roles of Hepatitis E virus (HEV), Torque teno virus (TTV), and GB virus C (GBV-C)/Hepatitis G virus (HGV) in acute viral hepatitis require further investigation.
  • Understanding co-infections and the etiology of non-A-C hepatitis is crucial for effective diagnosis and treatment.

Purpose of the Study:

  • To determine the prevalence of HEV, TTV, and GBV-C/HGV in patients with acute viral hepatitis A, B, and non-A-C.
  • To investigate the potential role of these viruses in the etiology of acute hepatitis.
  • To identify genotypes of TTV and GBV-C/HGV circulating in the studied population.

Main Methods:

  • Sera from 94 patients with acute hepatitis A, B, or non-A-C, and 71 blood donors were analyzed.
  • HEV antibodies (IgM and IgG) were detected using enzyme immunoassay.
  • TTV and GBV-C/HGV were detected and genotyped using nested PCR, sequencing, and phylogenetic analysis.

Main Results:

  • Anti-HEV IgG was detected in 38% of hepatitis A, 10% of hepatitis B, and 17% of non-A-C cases.
  • Anti-HEV IgM was found in 4 hepatitis A patients and 1 non-A-C hepatitis patient, suggesting co-infection or HEV etiology.
  • TTV and GBV-C/HGV were detected in 21% and 9% of hepatitis patients, respectively, and in 31% and 10% of donors; their presence was associated with lower aminotransferase levels and not linked to acute hepatitis etiology.

Conclusions:

  • Hepatitis E virus (HEV) co-infection may occur in acute hepatitis A cases and could be responsible for some sporadic non-A-C hepatitis cases in Salvador, Brazil.
  • TTV genotypes 1-4 and GBV-C/HGV genotypes 1-2 are prevalent in the studied population.
  • TTV and GBV-C/HGV infections do not appear to play a significant role in the etiology of acute hepatitis.

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