[Differential genetic pathway of duct and acinar carcinomas of the pancreas]
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Updated: Aug 17, 2026

Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture
Published on: February 11, 2019
1Department of Pathology, Saiseikai Chuwa Hospital, Nara, Japan.
Abstract:
Genetic pathways of various types of pancreatic carcinoma are described. There are many differences in the genetic pathway between duct carcinogenesis and acinar carcinogensis. K-ras mutation is a key event in the early stage of pancreatic duct carcinogenesis and various gene alterations accumulate from precancerous ductal lesions until the development of carcinomas. Therefore, inhibition of K-ras gene mutation might be important for the prevention, and the combination of therapeutic agents against some target genes might be needed for therapy of ductal carcinomas.
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