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Effect of electrolytes on the partition coefficient of irbesartan

C J Mbah1

  • 1DMI Inc., Wharton, NJ 07885-1600, USA.

Die Pharmazie
|May 28, 2005
PubMed

The effect of various electrolytes namely monovalent, divalent and trivalent on the partition coefficient of irbesartan between n-octanol and water systems was investigated at room temperature. It was found that all the electrolytes increase the partition coefficient of irbesartan. The uptake of irbesartan by the organic phase from the aqueous phase is increased with increasing salt concentration except for potassium iodide and aluminum chloride. The effect was found to depend on the size and charge of the ions present in solution.

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