Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Manipulating dendritic cells to induce regulatory T cells.

G Penna1, N Giarratana, S Amuchastegui

  • 1BioXell, Milan, Italy.

Microbes and Infection
|May 28, 2005
PubMed
Summary

Dendritic cells (DCs) can be manipulated to induce regulatory T cells, offering a potential strategy for managing chronic inflammatory diseases. This approach holds promise for conditions like autoimmune diseases and allograft rejection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing Fixed-Duration Ven-I Regimen in CLL: Expert Insight and AI Comparison.

Hematological oncology·2026
Same author

Cardiopulmonary and skeletal muscle strategies underlying exhaustive exercise in adults with glycogen storage disease type III.

Physiological reports·2026
Same author

Protective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling.

Frontiers in cardiovascular medicine·2024
Same author

Farnesoid X receptor activation by the novel agonist TC-100 (3α, 7α, 11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid) preserves the intestinal barrier integrity and promotes intestinal microbial reshaping in a mouse model of obstructed bile acid flow.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2022
Same author

Immunofluorescence mapping, electron microscopy and genetics in the diagnosis and sub-classification of inherited epidermolysis bullosa: a single-centre retrospective comparative study of 87 cases with long-term follow-up.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Linguistic analysis of autobiographical narratives in unipolar and bipolar mood disorders in light of multiple code theory.

Journal of affective disorders·2020

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are crucial in initiating and modulating T-cell-mediated immune responses.
  • Tolerogenic DCs possess the capacity to foster regulatory T cells (Tregs) with immunosuppressive functions.

Purpose of the Study:

  • To explore the potential of pharmacologically or biologically manipulating dendritic cells (DCs) to induce tolerogenic properties.
  • To investigate the therapeutic application of tolerogenic DCs in managing chronic inflammatory conditions.

Main Methods:

  • Focus on the manipulation of dendritic cells (DCs) using pharmacological and biological agents.
  • Emphasis on inducing suppressive regulatory T cell (Treg) activity.

Main Results:

  • Dendritic cells (DCs) can be modulated to promote regulatory T cell (Treg) development.

Related Experiment Videos

  • This modulation enables DCs to exert tolerogenic activities.

    • Conclusions:

    • Manipulating dendritic cells (DCs) to induce tolerogenic activities is a viable strategy.
    • This approach could offer new treatments for chronic inflammatory diseases, including autoimmune disorders and allograft rejection.