3NTPT: a newly discovered antifertility agent. V. Ovarian dysfunction in Dysdercus koenigii

A 4 h exposure to a residual film of 15 mg 1-(3-nitrophenyl)-4,4,6-trimethyl-1H,4H-pyrimidine-2-thiol (3NTPT) dissolved in 5 ml acetone significantly inhibited ovarian growth in Dysdercus koenigii. The ovaries of treated females remained small and the trophocytes, the trophic core, the prefollicular tissue and the oogonia completely degenerated. This was followed by degenerative changes in the follicular epithelium, the interfollicular tissue and the developing oocytes. Resorption of the oocytes reduced the vitellarium to an empty tube. The follicular epithelium of the resorbed oocytes protruded into the lumen, while the interfollicular tissue completely degenerated. By day 7 after treatment, the ovaries were completely dystrophic, and this state was not reversible.