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Related Experiment Videos

Endothelial intercellular adhesion molecule (ICAM)-2 regulates angiogenesis.

Miao-Tzu Huang1, Justin C Mason, Graeme M Birdsey

  • 1Imperial College, BHF Cardiovascular Sciences Unit, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom.

Blood
|May 28, 2005
PubMed
Summary

Intercellular adhesion molecule 2 (ICAM-2) is crucial for angiogenesis, regulating endothelial cell survival, migration, and tube formation. Its absence impairs blood vessel development, revealing a novel pathway for angiogenesis regulation.

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Area of Science:

  • Endothelial biology
  • Molecular biology
  • Angiogenesis research

Background:

  • Endothelial junctions are vital for vascular homeostasis, regulating cell trafficking, contact, survival, and apoptosis.
  • Key junctional adhesion molecules like VE-cadherin and PECAM mediate endothelial cell interactions and leukocyte transmigration.
  • Intercellular adhesion molecule 2 (ICAM-2), a leukocyte adhesion molecule, is expressed at endothelial junctions.

Purpose of the Study:

  • To investigate the role of endothelial ICAM-2 in mediating angiogenesis.
  • To elucidate the mechanisms by which ICAM-2 influences endothelial cell function and vascular development.

Main Methods:

  • Utilized ICAM-2-deficient mice and endothelial cells for in vitro and in vivo studies.
  • Assessed angiogenesis, cell migration, and apoptosis.

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  • Investigated ICAM-2 signaling pathways, including Rac activation in human umbilical vein endothelial cells (HUVECs).

    • Main Results:

    • ICAM-2 deficiency resulted in impaired angiogenesis both in vitro and in vivo.
    • ICAM-2 supports homophilic interactions, potentially involved in endothelial tube formation.
    • ICAM-2-deficient cells exhibited defective migration and increased apoptosis.
    • ICAM-2 signaling activated Rac GTPase, essential for endothelial tube formation and migration.

    Conclusions:

    • Endothelial ICAM-2 plays a significant role in regulating angiogenesis through multiple mechanisms.
    • ICAM-2 influences endothelial cell survival, migration, and Rac activation.
    • Identified a novel ICAM-2-mediated pathway regulating angiogenesis and a new mechanism for Rac activation.