Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in blood cell response following strenuous physical exercise.

H Kvernmo1, J O Olsen, B Osterud

  • 1Institute of Medical Biology, University of Tromsø, Norway.

European Journal of Applied Physiology and Occupational Physiology
|January 1, 1992
PubMed
Summary

Physical exercise impacts immune response. Highly trained athletes exhibit lower resting tumour necrosis factor (TNF) production, with exercise temporarily reducing monocyte responsiveness to lipopolysaccharide (LPS) stimulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The key roles of complement and tissue factor in Escherichia coli-induced coagulation in human whole blood.

Clinical and experimental immunology·2015
Same author

Procoagulant and proinflammatory effects of red blood cells on lipopolysaccharide-stimulated monocytes.

Journal of thrombosis and haemostasis : JTH·2015
Same author

Alterations in markers of coagulation and fibrinolysis in patients with Paroxysmal Nocturnal Hemoglobinuria before and during treatment with eculizumab.

Thrombosis research·2015
Same author

Circadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatonin.

Spinal cord·2015
Same author

The partial thromboplastin time: reply.

Journal of thrombosis and haemostasis : JTH·2014
Same author

C1-inhibitor efficiently inhibits Escherichia coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood.

Clinical and experimental immunology·2013

Area of Science:

  • Immunology
  • Exercise Physiology

Background:

  • Tumour necrosis factor (TNF) and tissue factor activity are key inflammatory mediators.
  • Lipopolysaccharide (LPS) is a potent stimulator of immune responses.

Purpose of the Study:

  • To investigate the effect of varying physical exercise intensities on TNF and tissue factor activity in healthy subjects.
  • To compare immune responses in athletes with different training frequencies.

Main Methods:

  • Blood samples from 25 healthy subjects (categorized by training frequency) were stimulated with LPS before and after exercise.
  • TNF production was measured in LPS-stimulated blood.
  • Tissue factor activity was also assessed.

Main Results:

  • Top athletes showed significantly lower resting TNF production compared to less trained individuals.

Related Experiment Videos

  • Immediately post-exercise, monocyte responsiveness to LPS stimulation was reduced across all groups.
  • The reduction in TNF production was most pronounced in highly trained individuals.

    • Conclusions:

    • Regular physical training, particularly at high intensity, may modulate innate immune responses.
    • Exercise acutely suppresses inflammatory mediator production, with varying effects based on training status.
    • Immune responses return to baseline levels within 6 hours post-exercise.