Depression and antidepressant use among people living with HIV in Hawaii: focus on Native Hawaiians

Timothy R Juday1, Suzanne M Richmond-Crumm

  • 1University of Hawaii at Manoa, Department of Public Health Sciences and Epidemiology, 1960 East-West Road Biomed D104F, Honolulu, HI 96822, USA. juday@hawaii.edu

Insights

Depression is common in people with HIV, but Native Hawaiians showed lower rates. Antidepressant use was similar across racial groups in this study of HIV-positive individuals in Hawaii.

Area of Science:

  • Medical research
  • Public health
  • Epidemiology

Background:

  • Depression prevalence and antidepressant use are understudied in the human immunodeficiency virus (HIV)-positive population.
  • Limited data exists specifically for HIV-positive Native Hawaiians regarding mental health conditions.

Purpose of the Study:

  • To investigate the prevalence of depression and antidepressant use among clients in Hawaii's HIV Seropositivity and Medical Management Program.
  • To examine racial and ethnic variations in depression rates and antidepressant use within this cohort.

Main Methods:

  • Cross-sectional study analyzing data from 1016 clients in Hawaii's HIV program between 2001-2002.
  • Data collection included self-reported depression status and antidepressant use.

Main Results:

  • 30% of clients reported experiencing depression.
  • Half of the clients reported current antidepressant use.
  • Native Hawaiians exhibited the lowest depression rates compared to other racial/ethnic groups.
  • Antidepressant usage did not significantly differ across racial or ethnic categories.

Conclusions:

  • Depression affects a significant portion of the HIV-positive population in Hawaii.
  • While Native Hawaiians had lower depression rates, overall antidepressant use was consistent across diverse groups.
  • Further research is needed to understand the specific mental health needs and disparities within the HIV-positive community, particularly among Native Hawaiians.

Related Concept Videos

Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs01:28

Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs

Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...