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Updated: Aug 17, 2026
PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
[Experimental study on polylactic glycolate acid microparticles with releasing-slowly vascular endothelial growth
Yang Chen1, Xinle Luo, Jiande Xiao
1Department of Orthopaedics, Shenzhen Second People's Hospital, Shenzhen Guangdong, 518035, PR China. chenyang@tom.com
Objective:
To observe the degradation of the polylactic glycolate acid (PLGA) microparticles with releasing-slowly vascular endothelial growth factor (VEGF) synthesized by the method of emulsification-diffusion.
Methods:
The method of emulsification-diffusion is to incorporate VEGF into microparticles composed of biodegradable PLGA. The controlled release of microparticles are acquired. The content of the VEGF released slowly from PLGA microparticles in vitro was detected with ELISA at different time.
Results:
We synthesized 100 releasing-slowly VEGF PLGA microparticles with the size of 0.20-0.33 microm by 5 times. The contents were 62 +/- 11 ng/L, 89 +/- 14 ng/L, and 127 +/- 19 ng/L in the 1st, the 2nd and the 3rd months after degradation, respectively.
Conclusion:
The PLGA microparticles with releasing-slowly VEGF can be synthesized by the method of emulsification-diffusion.
