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Sulfur-containing polybromoindoles from the Formosan red alga Laurencia brongniartii
Ali A El-Gamal1, Wei-Lung Wang, Chang-Yih Duh
1Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Abstract:
Five new sulfur-containing polybromoindoles, 2-methylsulfinyl-3-methylthio-4,5,6-tribromoindole (1), 3-methylsulfinyl-2,4,6-tribromoindole (2), 4,6-dibromo-2,3-di(methylsulfinyl)indole (3), 3,3'-bis(2'-methylsulfinyl-2-methylthio-4,6,4',6'-tetrabromo)indole (4), and 3,3-bis(4,6-dibromo-2-methylsulfinyl)indole (5), as well as seven known sulfur-containing polybromoindoles, 3-methylthio-2,4,6-tribromoindole (6), 3-methylthio-2,4,5,6-tetrabromoindole (7), 4,6-dibromo-2,3-di(methylthio)indole (8), 2,3-di(methylthio)-4,5,6-tribromoindole (9), 4,6-dibromo-2-methylsulfinyl-3-(methylthio)indole (10), 4,6-dibromo-2-(methylthio)indole (11), and 3,3-bis(4,6-dibromo-2-methylthio)indole (12), have been isolated from the Formosan red alga Laurencia brongniartii. The structures were elucidated by extensive spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
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