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Successful hormone treatment of orbital leiomyoma
Julia Wrede1, Burkhard Helmke, Marius Hartmann
1Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany.
Purpose:
To describe the successful hormone treatment of noncircumscribed orbital leiomyoma.
Design:
Case report.
Participant:
A 66-year-old woman with histologically proven orbital leiomyoma.
Methods:
Because surgical excision of the tumor was impossible, therapy with the gonadotropin-releasing hormone (GnRH) analog goserelin was performed.
Results:
Hormone treatment was well tolerated and no side effects were noted. The tumor regressed significantly during treatment. No recurrence occurred during a 5-year follow-up period.
Conclusions:
This report describes for the first time successful hormone treatment of a noncircumscribed orbital leiomyoma. Goserelin may have an antiproliferative effect on leiomyoma cells via membrane receptors for GnRH.