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Tissue Doppler velocities of mitral annulus and NT-proBNP in patients with heart failure

Martin Tretjak1, Franc Verovnik, Davorin Benko

  • 1Department of Cardiology, General Hospital Slovenj Gradec, Gosposvetska 1, 2380 Slovenj Gradec, Slovenia. martin.tretjak@siol.net

European Journal of Heart Failure
|June 1, 2005
PubMed

Insights

Early diastolic mitral annulus velocity measured by tissue Doppler imaging (TDI) strongly correlates with N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in heart failure (HF) patients. This provides a simple, accurate echocardiographic index for assessing HF severity.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Diagnostics

Background:

  • Pulsed wave tissue Doppler velocities of the mitral annulus are known indicators of left ventricular (LV) function.
  • Their utility in assessing LV dysfunction in unselected heart failure (HF) patients remains unclear.

Purpose of the Study:

  • To investigate the correlation between LV mitral annulus velocities measured by tissue Doppler imaging (TDI) and plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in HF patients.

Main Methods:

  • Measured early diastolic (E(m)) and systolic (S(m)) TDI velocities of the septal and lateral mitral annulus in 50 HF patients.
  • Compared these velocities with conventional echocardiographic parameters and plasma NT-proBNP levels.

Main Results:

  • Found significant correlations between NT-proBNP levels and E(m) velocity (r=-0.79), S(m) velocity (r=-0.43), and LV ejection fraction (r=-0.44).
  • In a multiple regression model, E(m) velocity was the strongest predictor of NT-proBNP levels (R(2)=0.733).

Conclusions:

  • Early diastolic mitral annulus velocity measured by TDI strongly correlates with plasma NT-proBNP levels.
  • TDI-derived early diastolic mitral annulus velocity is a simple, accurate, and reproducible echocardiographic index for heart failure.
Abstract

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