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Updated: Sep 21, 2026

Whole-mount Imaging of Mouse Embryo Sensory Axon Projections
Published on: December 9, 2014
Biological effects of TrkA and TrkB receptor signaling in neuroblastoma
Alexander Schramm1, Johannes H Schulte, Kathy Astrahantseff
1Division of Hematology/Oncology and Endocrinology, University Children's Hospital of Essen, Hufelandstrasse 55, 45122 Essen, Germany.
Abstract:
The Trk family consists of three receptor tyrosine kinases, each of which can be activated by one or more of four neurotrophins-NGF, BDNF, NT3 and NT4. Neurotrophins mediate their multiple effects through a number of distinct intracellular signaling cascades regulating such diverse biological responses as cell survival, proliferation and differentiation in normal and neoplastic neuronal cells. Expression of Trk receptors also plays an important role in the biology and clinical behavior of neuroblastomas. High expression of TrkA is present in neuroblastomas with favorable biological features and highly correlated with patient survival, whereas TrkB is mainly expressed on unfavorable, aggressive neuroblastomas. This short review discusses recent data on the biological roles of TrkA and TrkB signaling in neuroblastoma.
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