[Nerium oleander self poisoning treated with digoxin-specific antibodies]
B Bourgeois1, P Incagnoli, J Hanna
1Samu de Grenoble, CHU de Grenoble, BP 207, 38043 Grenoble, France. BBourgeois@chu-grenoble.fr
Annales Francaises D'Anesthesie Et De Reanimation
|June 1, 2005
Summary
A man survived a Nerium oleander overdose after emergency treatment with digoxin-specific antibody fragments. Despite initial bradycardia, the patient recovered fully, highlighting the effectiveness of this intervention for oleander poisoning.
Area of Science:
- Toxicology
- Cardiology
- Emergency Medicine
Background:
- Nerium oleander (oleander) ingestion can cause severe cardiotoxicity.
- Early intervention is crucial for managing oleander poisoning, particularly cardiac arrhythmias.
Observation:
- A 44-year-old male presented with bradycardia, confusion, and vomiting after ingesting Nerium oleander leaves.
- Prehospital treatment with digoxin-specific Fab antibody fragments (Digidot) was administered.
Findings:
- The patient experienced a second episode of severe bradycardia (25 bpm) despite initial antibody fragment treatment.
- Subsequent treatment led to rhythm stabilization, resolution of neurological symptoms and vomiting.
- The patient recovered uneventfully and was discharged within two days.
Implications:
- Digoxin-specific Fab antibody fragments may be effective in managing severe Nerium oleander cardiotoxicity.
- Prompt medical intervention is vital for improving outcomes in oleander poisoning cases.
- This case underscores the importance of advanced treatment options in prehospital emergency care for toxic ingestions.
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