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Human DNA repair genes, 2005.

Richard D Wood1, Michael Mitchell, Tomas Lindahl

  • 1University of Pittsburgh Cancer Institute, Hillman Cancer Center, Research Pavilion, Suite 2.6, 5117 Centre Avenue, Pittsburgh, PA 15213, USA. rdwood@pitt.edu

Mutation Research
|June 1, 2005
PubMed
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This study updates a comprehensive inventory of approximately 150 human DNA repair genes, crucial for understanding genetic stability and cellular responses to DNA damage.

Area of Science:

  • Genetics
  • Molecular Biology
  • Bioinformatics

Background:

  • DNA repair mechanisms are essential for maintaining genomic integrity.
  • Previous inventories of human DNA repair genes have been established.
  • Understanding these genes is critical for research into genetic instability and disease.

Purpose of the Study:

  • To present an updated inventory of human DNA repair genes.
  • To provide a comprehensive resource for researchers in genetics and molecular biology.
  • To highlight recent additions and revisions to the gene list.

Main Methods:

  • Compilation of a gene inventory based on functional roles in DNA repair.
  • Inclusion of genes involved in DNA damage response and genetic instability.

Related Experiment Videos

  • Cross-referencing with multiple biological databases for comprehensive data.

    • Main Results:

    • An updated inventory of approximately 150 human DNA repair genes is presented.
    • The inventory includes genes encoding DNA repair enzymes and related cellular response genes.
    • Approximately 25 new genes have been added since the 2001 version.

    Conclusions:

    • The updated human DNA repair gene table serves as a valuable research and reference tool.
    • This resource facilitates direct access to integrated genetic and sequence information.
    • The ongoing curation of DNA repair genes is vital for advancing genomic research.