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Related Experiment Videos

Snake venoms and coagulopathy.

Julian White1

  • 1Toxinology Dept, Women's and Children's Hospital, North Adelaide SA 5006, Australia. toxinaus@wch.sa.gov.au

Toxicon : Official Journal of the International Society on Toxinology
|June 1, 2005
PubMed
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Snakebite envenoming causes significant deaths and morbidity, with coagulopathy being a major factor. Antivenom is the primary treatment for snakebite coagulopathy, while other therapies may be ineffective or harmful.

Area of Science:

  • Toxicology
  • Hematology
  • Clinical Medicine

Background:

  • Snakebite envenoming impacts millions globally, leading to over 100,000 deaths annually.
  • Coagulopathy is a critical complication, significantly contributing to snakebite morbidity and mortality.
  • Understanding diverse coagulopathy types is crucial for effective patient management.

Purpose of the Study:

  • To review the clinical aspects of snakebite-induced coagulopathy.
  • To detail the various types of coagulopathies associated with snakebites.
  • To discuss diagnostic and treatment strategies for snakebite coagulopathy.

Main Methods:

  • Literature review of clinical aspects of snakebite coagulopathy.
  • Categorization of coagulopathy types (procoagulant, fibrinogen clotting, fibrinolytic, platelet-active, anticoagulant, thrombotic, haemorrhagic).

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  • Presentation of clinical laboratory findings for selected coagulopathy types.

    • Main Results:

    • Snakebite coagulopathy presents in various forms, affecting blood clotting mechanisms.
    • Clinical laboratory findings vary depending on the specific type of snakebite coagulopathy.
    • Antivenom is the most effective treatment when available.

    Conclusions:

    • Effective management of snakebite coagulopathy requires accurate diagnosis of its type.
    • Standard coagulopathy treatments like factor replacement and heparin are often unsuitable for snakebite cases.
    • Antivenom remains the cornerstone of treatment for venom-induced coagulopathy.