Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Haplotype-based genetics in mice and rats.

Edwin Cuppen1

  • 1Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands. ecuppen@niob.nkaw.nl

Trends in Genetics : TIG
|June 1, 2005
PubMed
Summary

Haplotype blocks, used for genetic mapping in rodents, are based on limited polymorphism data. New high-density SNP data reveal complex patterns, requiring a reevaluation of their utility in genetic association studies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomics comes of age: From research tool to routine care.

Journal of internal medicine·2026
Same author

Author Correction: Real-world clinical utility of tumor whole-genome sequencing in solid cancers.

Nature medicine·2026
Same author

Real-world clinical utility of tumor whole-genome sequencing in solid cancers.

Nature medicine·2026
Same author

Clinical implications of whole genome sequencing in metastatic colorectal cancer.

Oncogene·2025
Same author

Whole genome sequencing-based analysis of genetic predisposition to adult glioblastoma.

NPJ genomic medicine·2025
Same author

Genomic distinctions in adolescent and young adult cancer: A comprehensive review.

Cancer treatment reviews·2025

Area of Science:

  • Genomics
  • Population Genetics
  • Bioinformatics

Background:

  • Haplotype blocks represent genomic segments with linked polymorphisms, suggesting shared ancestry.
  • These blocks and their strain-distribution patterns are crucial for genetic association and mapping in laboratory animals.
  • Current methods for characterizing haplotype blocks rely on computational algorithms and incomplete polymorphism data.

Purpose of the Study:

  • To investigate the utility of haplotype blocks for genetic mapping in commonly used mouse inbred strains.
  • To assess the impact of high-density single nucleotide polymorphism (SNP) screening on understanding haplotype block patterns.
  • To re-evaluate the expectations for using haplotype blocks in genetic association studies.

Main Methods:

  • Computational algorithms for haplotype block characterization.
  • High-density single nucleotide polymorphism (SNP) screening in laboratory mouse strains.
  • Analysis of strain-distribution patterns of polymorphisms.

Main Results:

  • Haplotype block characterization relies on computational methods and incomplete polymorphism inventories.
  • High-density SNP screening in mouse strains revealed complex, unexpected patterns.
  • Deduced strain-distribution patterns of haplotype blocks may not be as straightforward as previously assumed.

Conclusions:

  • The complex patterns observed necessitate a reevaluation of the current understanding and application of haplotype blocks in genetic mapping.
  • Expectations for the power of haplotype blocks in genetic association studies, particularly in mice, need to be revisited.
  • Further research is required to refine methods for haplotype block analysis and interpretation in light of new genomic data.

Related Experiment Videos