[Thrombocytopenia due to glibenclamide]

A 45-year-old male, admitted for severe thrombocytopenia and bleeding tendency related to treatment with glibenclamide is presented. Thrombocytopenic purpura associated with glibenclamide, a short-acting sulfonylurea, is rare. We suggest that platelet counts be performed shortly after initiation of glibenclamide administration, and every 3 months thereafter.