Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Variations in differential gene expression patterns across multiple brain regions in schizophrenia.

P Katsel1, K L Davis, J M Gorman

  • 1Department of Psychiatry, The Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029-6575, USA.

Schizophrenia Research
|June 1, 2005
PubMed
Summary

Gene expression in schizophrenia (SZ) is most altered in the superior temporal cortex, cingulate cortex, and hippocampus, not the commonly studied dorsolateral prefrontal cortex. These findings highlight key brain regions for further SZ research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Application of an Intermittency Model for Laminar, Transitional, and Turbulent Internal Flows.

Journal of fluids engineering·2021
Same author

The emerging therapeutic role of RNA interference in disorders of the central nervous system.

Clinical pharmacology and therapeutics·2011
Same author

Towards a paradigm shift in neuropsychiatry.

CNS spectrums·2006
Same author

From the theoretical to the practical: approaches to the management of neuropsychiatry.

CNS spectrums·2005
Same author

Sharing memories: the brain and the immune system.

CNS spectrums·2005
Same author

Environmental Stress and the Brain's Reaction.

CNS spectrums·2004

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Schizophrenia (SZ) research has predominantly focused on gene expression in the dorsolateral prefrontal cortex.
  • Evidence suggests other brain regions are implicated in SZ, but comprehensive studies are less frequent.

Purpose of the Study:

  • To investigate and compare gene expression alterations across multiple brain regions in individuals with schizophrenia.
  • To identify brain regions most affected by gene expression changes in schizophrenia.

Main Methods:

  • Postmortem gene expression analysis using Affymetrix GeneChip microarrays.
  • Examined frontal, cingulate, temporal, parietal, and occipital cortices, hippocampus, caudate nucleus, and putamen.
  • Compared gene expression in 13 individuals with schizophrenia against 13 control subjects.

Related Experiment Videos

Main Results:

  • The superior temporal cortex (BA22) exhibited the highest number of altered transcripts (~1200) in schizophrenia subjects.
  • Anterior/posterior cingulate cortices and the hippocampus showed significant alterations, but fewer than the temporal cortex.
  • The dorsolateral prefrontal cortex (BA46) displayed substantially fewer gene expression changes (~33).

Conclusions:

  • The superior temporal cortex, cingulate cortices, and hippocampus are significantly implicated in schizophrenia.
  • These regions may be more susceptible to the disease processes of schizophrenia than previously emphasized areas.
  • Findings redirect focus towards these regions for understanding schizophrenia pathophysiology.