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Related Experiment Videos

Does vasculogenic mimicry exist in astrocytoma?

Wei-Ying Yue1, Zhong-Ping Chen

  • 1Department of Neurosurgery and Neuro-oncology, Cancer Center, Sun Yat-Sen University, Guangzhou, PR China 510060.

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
|June 1, 2005
PubMed
Summary

Vasculogenic mimicry (VM), a tumor vascularization pattern, was investigated in astrocytomas. This study found evidence of VM in high-grade astrocytomas, suggesting a novel vascularization mechanism in these brain tumors.

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Area of Science:

  • Neuro-oncology
  • Cancer Biology
  • Tumor Microenvironment

Background:

  • Vasculogenic mimicry (VM) is a tumor vascularization mechanism observed in various cancers, including melanoma.
  • The presence and significance of VM in astrocytomas, a type of brain tumor, remain largely unexplored.
  • Understanding tumor vascularization is crucial for developing effective therapeutic strategies in neuro-oncology.

Purpose of the Study:

  • To investigate the existence of vasculogenic mimicry (VM) in astrocytomas of different World Health Organization (WHO) grades.
  • To characterize the histological features of potential VM in astrocytoma tissues.
  • To explore the expression patterns of endothelial and glial markers in relation to VM.

Main Methods:

  • Analysis of 45 astrocytoma samples (15 each of WHO grade II, III, and IV).

Related Experiment Videos

  • Dual staining using CD34 (endothelial marker) and Periodic Acid-Schiff (PAS) to identify vascular structures.
  • Immunohistochemical assessment for laminin and glial fibrillary acidic protein (GFAP) expression.

    • Main Results:

    • Endothelium-lined vessels positive for PAS, laminin, and endothelial markers were observed in astrocytomas.
    • A PAS-positive pattern consistent with vasculogenic mimicry (VM) was identified in two cases of grade IV astrocytoma (glioblastoma).
    • These VM channels contained erythrocytes, stained positive for PAS and laminin, and negative for CD34, with some co-expression suggesting integration with normal vasculature. Anaplastic tumor cells in glioblastoma showed CD34 expression and loss of GFAP.

    Conclusions:

    • Vasculogenic mimicry (VM) phenomenon is present in a subset of malignant astrocytomas, particularly glioblastoma.
    • Tumor cells in high-grade astrocytomas may exhibit altered marker expression, including CD34, and lose astrocyte-specific proteins.
    • The findings suggest that VM may represent an alternative vascularization pathway in aggressive astrocytomas, impacting tumor biology and potentially treatment resistance.