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Related Experiment Videos

Objective perimetry using the multifocal visual evoked potential in central visual pathway lesions.

A I Klistorner1, S L Graham, J Grigg

  • 1Save Sight Institute, Sydney Eye Hospital, Macquarie Street, PO Box 1614, Sydney 2001, Australia.

The British Journal of Ophthalmology
|June 1, 2005
PubMed
Summary

The multifocal pattern visual evoked potential (mVEP) effectively detects visual field loss in hemianopic lesions. However, it may not identify quadrantanopic field loss caused by extra-striate cortical lesions.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Clinical Electrophysiology

Background:

  • Neurological lesions affecting the visual pathway can cause significant visual field deficits.
  • Accurate detection of field loss is crucial for diagnosis and management of visual pathway disorders.
  • The multifocal pattern visual evoked potential (mVEP) is an electrophysiological technique used to assess visual function.

Purpose of the Study:

  • To evaluate the efficacy of the multifocal pattern visual evoked potential (mVEP) in detecting visual field loss.
  • To determine if mVEP can differentiate between lesions in the striate and extra-striate cortex.
  • To compare mVEP findings with subjective visual field testing and neuroimaging results.

Main Methods:

  • Retrospective review of mVEP recordings from patients with central neurological lesions.

Related Experiment Videos

  • Utilized the AccuMap V1.3 objective perimeter with a four-channel occipital electrode array.
  • Analyzed 19 patients with hemianopias (hemianopic and quadrantanopic types), comparing mVEP with subjective fields and CT/MRI.

    • Main Results:

    • mVEP successfully detected field loss in all 12 hemianopic cases (homonymous and bitemporal), with good scotoma localization.
    • Topographic distribution on mVEP showed similarity, but not identity, to subjective visual field testing.
    • Only 4 of 7 quadrantanopic hemianopias showed corresponding mVEP loss; 3 normal mVEPs correlated with extra-striate lesions.

    Conclusions:

    • mVEP is capable of detecting visual field loss resulting from cortical lesions.
    • mVEP may be less sensitive in detecting quadrantanopic field loss, particularly with extra-striate lesions.
    • Findings suggest mVEP originates in V1 striate cortex and can help distinguish striate from extra-striate lesions, necessitating caution in interpreting quadrantic field loss.