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Meropenem.

Dheeraj Shah1, Manish Narang

  • 1Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110 095, India. shahdheeraj@hotmail.com

Indian Pediatrics
|June 1, 2005
PubMed
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Meropenem is a broad-spectrum carbapenem antibiotic effective against many bacteria, including in severe pediatric infections like meningitis. Reserve its use for difficult cases to prevent resistance.

Area of Science:

  • Pharmacology
  • Microbiology
  • Pediatrics

Background:

  • Meropenem is a carbapenem antibiotic with broad-spectrum activity.
  • It exhibits stability against common bacterial beta-lactamases.

Purpose of the Study:

  • To evaluate the utility of meropenem in treating severe pediatric infections.
  • To assess its efficacy in meningitis and infections in neutropenic children.

Main Methods:

  • Clinical data review of meropenem use in hospitalized children.
  • Assessment of meropenem's pharmacokinetic profile, including CSF penetration.

Main Results:

  • Meropenem demonstrated efficacy in severe gram-negative, gram-positive, and anaerobic infections.

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  • Good cerebrospinal fluid (CSF) penetration supports its use in childhood meningitis.

    • Conclusions:

    • Meropenem is highly useful for severe pediatric infections, particularly meningitis and in neutropenic children.
    • Due to resistance concerns, it should be reserved for difficult-to-treat infections or treatment failures.