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Related Experiment Videos

Heart autonomic function in overweight adolescents.

Juan-Manuel Guízar1, Rosalía Ahuatzin, Norma Amador

  • 1Epidemiological Research Unit, Mexican Institute of Social Security, Leon, Mexico.

Indian Pediatrics
|June 1, 2005
PubMed
Summary

Obese adolescents exhibit heightened sympathetic cardiac activity, linked to elevated leptin and systolic blood pressure. These factors contribute to increased sympathetic tone in this population.

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Area of Science:

  • Cardiology
  • Pediatrics
  • Endocrinology

Background:

  • Obesity in adolescents is a growing concern.
  • Sympathetic cardiac activity plays a role in cardiovascular health.
  • Understanding factors influencing sympathetic activity in obese youth is crucial.

Purpose of the Study:

  • To compare factors associated with sympathetic cardiac activity in obese versus normal-weight male adolescents.
  • To identify specific physiological markers linked to sympathetic activity in adolescent obesity.

Main Methods:

  • Cross-sectional study of 70 male adolescents (34 obese, 36 normal weight).
  • Fasting measurements of insulin, leptin, glucose, and blood pressure.
  • Heart rate variability assessed using power spectral analysis (LF/HF index).

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Main Results:

  • Obese adolescents showed higher systolic blood pressure, insulin, leptin, and LF/HF index.
  • Lower standard deviation of normal RR intervals and total power were observed in obese adolescents.
  • Leptin and systolic blood pressure were significant predictors of the LF/HF index (R2 = 0.18, P = 0.004).

Conclusions:

  • Obese male adolescents have increased sympathetic cardiac activity.
  • Elevated leptin and systolic blood pressure are associated with higher sympathetic activity in this group.
  • These findings highlight potential targets for managing cardiovascular risk in adolescent obesity.