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Related Experiment Videos

[Digital ischaemia and gemcitabine. Two new cases].

S Blaise1, H Appeltants, P H Carpentier

  • 1Service de Médecine Interne, CHU Michallon, BP 217, 38043 Grenoble Cedex 09. SBlaise@chu-grenoble.fr

Journal Des Maladies Vasculaires
|June 1, 2005
PubMed
Summary

Gemcitabine chemotherapy can cause digital ischemia, a rare but serious adverse effect. This study highlights two cases and literature reviews, suggesting increased awareness and precautions are needed.

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Area of Science:

  • Oncology
  • Vascular Medicine
  • Pharmacology

Background:

  • Digital ischemia is a known complication of cancer treatment, often linked to paraneoplastic syndromes.
  • While various chemotherapy agents can cause adverse effects, gemcitabine has been anecdotally associated with vascular complications.
  • Understanding the spectrum of chemotherapy-induced toxicities is crucial for patient safety and effective treatment.

Observation:

  • Two distinct cases of digital ischemia are presented, strongly suggesting a link to gemcitabine administration.
  • The first case involved a patient with metastatic squamous cell carcinoma treated with gemcitabine, who developed toxic vascularitis.
  • The second case concerned a patient with bladder carcinoma who developed gemcitabine-induced arterial thrombosis.

Findings:

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  • Gemcitabine is implicated as a potential cause of digital ischemia, a complication that may be underestimated.
  • Literature review identified nine additional cases of gemcitabine-associated digital ischemia.
  • Other reported vascular side effects of gemcitabine include thrombotic microangiopathy and veno-occlusive disease.

Implications:

  • Increased vigilance for digital ischemia is warranted in patients receiving gemcitabine, particularly those with pre-existing vascular conditions.
  • Further research into the pathogenic mechanisms of gemcitabine-induced vascular toxicity is needed.
  • Early recognition and management, including drug cessation, can lead to favorable outcomes.