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Related Experiment Videos

Uric acid monohydrate--a new urinary calculus phase.

Gernot Schubert1, Günter Reck, Harald Jancke

  • 1Vivantes Klinikum im Friedrichshain, Institut für Laboratoriumsdiagnostik, Landsberger Allee 49, 10249 Berlin, Germany. gernot.schubert@vivantes.de

Urological Research
|June 1, 2005
PubMed
Summary
This summary is machine-generated.

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A rare form of urinary stone, uric acid monohydrate, was identified using X-ray crystallography. This finding suggests it may have been previously overlooked in stone analysis due to its similarity to other uric acid forms.

Area of Science:

  • Urology
  • Crystallography
  • Biochemistry

Background:

  • Urinary calculi analysis involves identifying stone components.
  • Over 100,000 urinary calculi analyzed since 1972.
  • 15 specimens showed characteristics of an unidentified substance.

Purpose of the Study:

  • To identify an unknown substance found in urinary calculi.
  • To characterize the crystal structure and properties of this substance.
  • To report the first instance of uric acid monohydrate as a urinary stone component.

Main Methods:

  • X-ray crystallography for structural analysis.
  • Infrared spectroscopy for spectral comparison.
  • Solid-state Nuclear Magnetic Resonance (NMR) spectroscopy for material analysis.

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Main Results:

  • The unknown substance was identified as uric acid monohydrate.
  • Uric acid monohydrate crystallizes in the monoclinic space group P2(1)/c, forming layered structures.
  • This form is rare (0.015% frequency) and often contaminated with amorphous aliphatic material, unlike other uric acid forms.

Conclusions:

  • Uric acid monohydrate is a newly identified component of urinary stones.
  • Its structural similarity to other forms may lead to it being overlooked in routine analysis.
  • The presence of amorphous aliphatic material may play a role in its formation.