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Updated: Jul 25, 2026

Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells
Published on: April 25, 2018
Disordered RNA chaperone proteins: from functions to disease
R Ivanyi-Nagy1, L Davidovic, E W Khandjian
1Unité de Virologie Humaine (412), Ecole Normale Supérieure de Lyon et Institut National de la Santé et de la Recherche Médicale, IFR 128, 46 allée d'Italie, 69 364 Lyon, France.
Abstract:
RNA chaperones are ubiquitous proteins that play pivotal roles in cellular RNA metabolism and RNA virus replication. Here we propose that they act by organizing complex and highly dynamic networks of RNA-RNA, RNA-protein and protein-protein interactions. How this is achieved and how their malfunction may lead to disease will be discussed through the examples of human immunodeficiency virus type 1 nucleocapsid protein (NCp7), the fragile X mental retardation protein and the prion protein.
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